GENERIC NAME: ABACAVIR/LAMIVUDINE/ZIDOVUDINE - ORAL (a-BAK-a-vir/la-MIV-ue-deen/zye-DOE-vue-deen)
BRAND NAME(S): Trizivir
Warning |Medication Uses|How To Use|Side Effects|Precautions|Drug Interactions|Overdose|Notes|Missed Dose|Storage
WARNING:In some patients, theabacavirin this product has caused a serious (sometimes fatal)allergic reaction. Your doctor may order a blood test to measure your risk before you start this medication or take it again. If the blood test shows you are at greater risk, your doctor should discuss the risks and benefits of abacavir and other treatment choices with you. Symptoms of anallergicreaction may include any of the following:rash,itching/swelling (especially of the face/tongue/throat), severedizziness, troublebreathing,fever, extremetiredness,恶心想吐,vomiting,diarrhea,stomach pain, muscle aches,sore throat,mouth sores, orcough. Get medical help right away if you experience any of these symptoms. If you have stopped taking abacavir because of an allergic reaction, you must never take any form of abacavir again. Notify all of your doctors and pharmacists if you have stopped taking abacavir due to an allergic reaction. Read the warning card provided with this medication for more details.
Thezidovudinein this product can decrease bone marrow function, which may lead to low numbers of red and white blood cells. A low number of红细胞can lead to贫血. A low number of white blood cells can decrease your body's ability to fight serious, life-threatening infections. These serious side effects occur more frequently in people with advancedHIVdisease (AIDS）.Get medical help right away if you develop any signs of贫血(such as unusual tiredness, fast breathing,pale skin, fast heartbeat) or signs of infection (such asfever,chills,cough, persistentsore throat）.Your doctor will check your blood cell counts while you are taking this medication to decrease the risk of these side effects.
Zidovudine may also cause muscle problems. Get medical help right away if you develop signs of muscle problems (such as wasting or decrease in muscle size,weight loss, muscleweakness/pain/tenderness).
Rarely,abacavir/lamivudine/zidovudine has caused severe (sometimes fatal)liverproblems and a certain metabolic problem (lactic acidosis). Get medical help right away if you develop any of the following symptoms:恶心想吐,vomiting, stomach/abdominal pain, unusual tiredness,dark urine, yellowing eyes/skin, deep/rapid breathing, or drowsiness. These serious side effects may occur more often in women andobesepatients.
如果你有hepatitis Binfection andHIV, you may have a serious worsening ofhepatitissymptoms if you stop takinglamivudine. Talk with your doctor before stopping this medication. Your doctor will monitorliver testsfor several months after you stop lamivudine. Get medical help right away if you develop symptoms of worsening liver problems.
USES:This product contains 3drugs: abacavir, lamivudine, and zidovudine. It is used alone or with otherHIV药物来帮助控制艾滋病毒感染。它帮助s to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections,cancer) and improves your quality of life. Abacavir, lamivudine, and zidovudine all belong to a class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs).Abacavir/lamivudine/zidovudine is not a cure for HIV infection. To decrease your risk of spreading HIV disease to others, do all of the following: (1) continue to take all HIV medications exactly as prescribed by your doctor, (2) always use an effective barrier method (latex or polyurethanecondoms/dental dams) during all sexual activity, and (3) do not share personal items (such as needles/syringes, toothbrushes, and razors) that may have contacted blood or other body fluids. Consult your doctor or pharmacist for more details.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This product may also be used to reduce the risk of getting HIV infection after contact with the virus. Consult your doctor for more details.
HOW TO USE:读用药指南和警告牌d by your pharmacist before you start taking abacavir/lamivudine/zidovudine and each time you get a refill. Carry the Warning Card with you at all times. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth with or without food, usually twice daily or as directed by your doctor. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.Because this combination product has fixed doses of abacavir, lamivudine, and zidovudine, it should only be used if your doctor has determined that the doses of all 3 medications in this product are right for you. This product is not to be used in patients weighing less than 40 kilograms (88 pounds).If you stop taking any medication containing abacavir even for a short time and then restart the drug, you have an increased chance of developing a very serious (possibly fatal) allergic reaction. Refill your medication before you run out. Do not stop treatment unless directed by your doctor. Before restarting any medication containing abacavir, consult your doctor or pharmacist, and be sure you have easy access to medical care.It is very important to continue taking this medication (and other HIV medications) exactly as prescribed by your doctor. Do not skip any doses. Do not increase your dose, take this drug more often than prescribed, or stop taking it (or other HIV medicines) even for a short time unless directed to do so by your doctor. Skipping or changing your dose without approval from your doctor may cause the amount of virus to increase, make the infection more difficult to treat (resistant), or worsen side effects.This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day.
SLIDESHOW
A Timeline of the HIV/AIDS PandemicSee SlideshowSIDE EFFECTS:看到艾尔so Warning and How to Use sections.Headache, tiredness, weakness, nausea, vomiting,loss of appetite,diarrhea,dizziness, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Some people may experience worsening of a previous medical condition (such as an old infection) as their immune systems improve, or develop new conditions because their immune systems have become overactive. This reaction may occur at any time (soon after starting HIV treatment or many months later). Tell your doctor right away if you have any serious side effects, including: unexplainedweight loss, persistent muscle aches/weakness,joint pain, numbness/tingling of the hands/feet/arms/legs, severe tiredness, vision changes, severe/persistentheadaches, signs of infection (such as fever, chills, trouble breathing, cough, non-healing skin sores), signs of an overactive thyroid (such as irritability, nervousness, heat intolerance, fast/pounding/irregular heartbeat,bulging eyes, unusual growth in the neck/thyroid known as a goiter), signs of a certain nerve problem known asGuillain-Barre Syndrome(such as difficulty breathing/swallowing/moving your eyes, drooping face,paralysis, slurred speech).Tell your doctor right away if you have any serious side effects, including: mental/mood changes(such asdepression,焦虑),easy bruising/bleeding, skin/nail color changes.Get medical help right away if you have any very serious side effects, including: signs ofpancreatitis(such as nausea, vomiting, stomach/abdominal/back pain, fever).Changes in body fat may occur while you are taking this medication (such as increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of treatment with your doctor, as well as the possible use ofexerciseto reduce this side effect.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS:Before taking abacavir/lamivudine/zidovudine, tell your doctor or pharmacist if you are allergic to any of these drugs; or if you have any otherallergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems (such ashepatitis Bor C,cirrhosis), disease of the pancreas (pancreatitis),alcoholuse, low red/white blood cell counts.Abacavir may increase your risk of aheart attack. Discuss the risks and benefits of treatment with your doctor and ways to lower your risk ofheart disease. Tell your doctor if you haveheartproblems, if you smoke, or if you have other conditions that increase your risk ofheart disease, such ashigh blood pressure,diabetes, or highcholesterol levels.This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholicbeverages, because they can increase dizziness and increase the risk of liver problems and pancreatitis.Children may be more sensitive to the side effects of this drug, especially pancreatitis.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Duringpregnancy, this medication should be used only when clearly needed. However, HIV medicines are now usually given topregnantwomen with HIV. Treatment has been shown to decrease the risk of HIV transmission to the baby. Abacavir/lamivudine/zidovudine may be part of that treatment. Discuss the risks and benefits with your doctor.It is not known if abacavir passes intobreast milk. However,lamivudine and zidovudinepass into breast milk. Because breast milk can transmit HIV, do notbreast-feed.
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DRUG INTERACTIONS:Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include:interferonalfa,methadone,丙磺舒,ribavirin,司他夫定,zalcitabine, drugs that may decrease bone marrow function or lower blood cell counts (such as ganciclovir,trimethoprim,cancerchemotherapyincluding doxorubicin), drugs that may affect the kidneys (includingNSAIDssuch asibuprofenornaproxen）.其他medications can affect the removal of zidovudine from your body, which may affect how abacavir/lamivudine/zidovudine works. Examples includefluconazole, rifampin,valproic acid, among others.If you are also takingclarithromycin, take this medication at least 2 hours apart from your clarithromycin dose.Do not take other products that contain abacavir, lamivudine, or zidovudine with this medication.Emtricitabineis similar to lamivudine and should not be taken with this medication.
OVERDOSE:If overdose is suspected, contact apoison controlcenter or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES:Do not share this medication with others.Laboratory and/or medical tests (such as blood cell counts/tests, liver tests, kidney tests, viral load, T-cell counts) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.Keep all medical and laboratory appointments.
MISSED DOSE:If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE:Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.Do notflushmedications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised January 2014. Copyright(c) 2014 First Databank, Inc.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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