What are the uses for bepridil?
Bepridil is prescribed for patients withangina pectoris(heartpain) due tocoronary artery disease.
Vascor (bepridil hydrochloride) is indicated for the treatment of chronic stableangina(classic effort-associated angina). Because Vascor (bepridil) has caused serious ventricular arrhythmias, includingtorsades de pointestype ventricular tachycardia, and the occurrence of cases of agranulocytosis associated with its use (see WARNINGS), it should be reserved for patients who have failed to respond optimally to, or are intolerant of, other anti-anginal medication.
Vascor (bepridil) may be used alone or in combination withbeta-blockersand/ornitrates. Controlled clinical studies have shown an added effect when Vascor (bepridil) is administered to patients already receivingpropranolol.
Is bepridil available as a generic drug?
No
Do I need a prescription for bepridil?
Yes
What are the side effects of bepridil?
- Bepridil can cause very serious cardiac arrhythmias. The risk is increased in patients with a specific electrocardiographic abnormality called QT prolongation and in patients with low blood concentrations of potassium or magnesium.
- Bepridil also can cause increased or decreased heart rate and other abnormal rhythms.
Other side effects that can occur among patients taking bepridil include:
- flu-like symptoms,
- muscle aches,
- fever,
- nausea,
- vomiting,
- loss of appetite,
- constipation,
- gas,
- stomach ache,
- dry mouth,
- diarrhea,
- headache,
- fatigue,
- nervousness,
- drowsiness,
- dizziness,
- depression,
- inability tosleep,
- blurred vision,
- impotence, and
- reduction in sexual drive.
What is the dosage for bepridil?
Bepridil usually is taken once daily. It can be taken with meals or at bedtime ifnauseais a problem.
SLIDESHOW
See SlideshowWhich drugs or supplements interact with bepridil?
- Bepridil can reduce the strength with which the heart muscle contracts.Drugswhich also have this effect when given together with bepridil could seriously reduce contraction of the heart and possibly precipitatecongestive heart failure. Such drugs includequinidine(Quinaglute; Duraquin; Quinidex),procainamide(Procan-SR; Pronestyl),disopyramide(Norpace),flecainide(Tambocor),verapamil(Calan;Isoptin; Covera;Verelan),diltiazem(Cardizem;Tiazac; Dilacor), and all beta-blockers, for example,atenolol(Tenormin).
- Bepridil slows the ability of the heart's muscle to recover electrically and get ready for the next contraction. Other drugs which have the same effect could interact with bepridil, possibly causing serious problems withabnormal heart rhythmsand should be used cautiously if at all with bepridil. Such drugs include quinidine (Quinaglute; Duraquin; Quinidex), procainamide (Procan-SR; Pronestyl), disopyramide (Norpace), flecainide (Tambocor), andtricyclic antidepressants, for example,amitriptyline(Elavil,Endep).
- Bepridil may increase levels ofdigoxin(Lanoxin) in the blood, thereby increasing the risk of digoxin toxicity.
- Diuretics, for example,furosemide(Lasix),bumetanide(Bumex),torsemideDemadex),hydrochlorothiazide(Hydrodiuril),chlorthalidone(Hygroton),metolazone(Zaroxolyn) may cause a reduction in blood potassium concentrations thereby increasing the risk of bepridil-induced abnormal heart rhythms.
Is bepridil safe to take if I'm pregnant or breastfeeding?
- Bepridil crosses the placenta, and therefore should not be used duringpregnancyunless the benefit to the mother outweighs the potential but unknown risk to the fetus.
- Bepridil is secreted intobreast milkand therefore should not be used bybreastfeedingmothers unless benefit to the mother clearly outweighs the potential but unknown risk to the infant.
What else should I know about bepridil?
What preparations of bepridil are available?
Tablets: 200 mg.
How should I keep bepridil stored?
Tablets should be stored at room temperature, 15C to 30 C (59 F to 86 F).
Health News
Summary
Bepridil (Vascor, Bepadin) is a drug prescribed for the treatment of angina pectoris due to coronary artery disease. Bepridil is no longer available in the US. Side effects, drug interactions, dosage, and pregnancy and breastfeeding safety should be reviewed prior to taking this medication.
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Medications & Supplements
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- amlodipine (Norvasc)
- Calcium Channel Blockers (CCBs)
- diltiazem (Cardizem, Cardizem CD, Cardizem LA, Tiazac, Cartia XT, Diltzac, Dilt-CD, and several oth)
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- felodipine (Plendil)
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- nisoldipine (Sular)
- Vascor (bepridil hydrochloride) Side Effects, Warnings, and Drug Interactions
Prevention & Wellness
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First section is courtesy of the U.S. Food and Drug Administration