diphenhydramine - injection, Benadryl

BRAND NAME(S): Benadryl

Medication Uses|How To Use|Side Effects|Precautions|Drug Interactions|Overdose|Notes|Missed Dose|Storage

USES:Diphenhydramineinjection is anantihistamineused to treat life-threateningallergicreactions (anaphylaxis)以及epinephrine and other treatments. It is also used to relieve symptoms of householdallergies,hay feverand thecommon coldwhen medication cannot be given by mouth. Commonallergy symptomsrelieved byantihistaminesincluderash,itching,watery eyes,itchyeyes/nose/throat,cough,runny noseandsneezing.It is also used to treatnausea,vomitinganddizzinesscaused bymotion sicknesswhen medication cannot be given by mouth. Diphenhydramine works by blocking a certain natural substance (histamine) that your body makes during anallergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine).Diphenhydramine should not be used in newborns or premature infants because of an increased risk of side effects.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.Diphenhydramine injection is also used alone or with other medications to treat shaking (tremor) and musclestiffnesscaused by帕金森病when medication cannot be given by mouth. It may also be used to treat side effects of certain psychiatricdrugssuch as involuntary movements and muscle stiffness (e.g., EPS). It works by blocking acetylcholine. (See also Uses section.)

HOW TO USE:This medication is injected into a vein (IV) no faster than 25 milligrams per minute, or deeply into a muscle as directed by your doctor. Be very careful to inject into a vein or muscle and not into the skin or just under the skin. If this medication is injected into or just under the skin, it can destroy the skin and tissues around the injection site (necrosis).If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.Do not use this medication more often than prescribed. Your dosage is based on your medical condition and response to therapy. Inform your doctor if your condition does not improve or if it worsens.

SIDE EFFECTS:Drowsiness,dizziness,headache, irritability, stomach upset, vision changes (e.g.,blurred vision), decreased coordination,constipation, ordry mouth/nose/throat may occur. These effects may decrease as your body adjusts to the medication. If they persist or become bothersome, inform your doctor.To relievedry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use a saliva substitute. Diphenhydramine can dry up and thicken themucusin yourlungs, making it more difficult to breathe and clear your lungs. To help prevent this effect, be sure to drink plenty of fluids unless otherwise directed by your physician.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes(such as restlessness,confusion), pounding/irregular heartbeat,ringing in the ears,seizure,difficulty urinating。这种药物是非常严重的过敏反应unlikely, but get medical help right away if it occurs. Symptoms of a serious allergic reaction may include:rash,itching/swelling (especially of the face/tongue/throat), severe dizziness, troublebreathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS:Before using diphenhydramine, tell your doctor or pharmacist if you are allergic to it; or if you have any otherallergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g.,asthma,emphysema),glaucoma,heartproblems,high blood pressure,liver disease, mental/mood disorders,seizures, stomach problems (e.g., ulcers, obstruction), overactive thyroid, difficulty urinating (e.g.,enlarged prostate,urinary retention).This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit the use ofalcoholand certain other medications that cause drowsiness. (See alsoDrug Interactions.)To minimize dizziness andlightheadedness, get up slowly when rising from a seated or lying position.Caution is advised when using this drug in children because they are more sensitive to the effects of antihistamines. This drug can often cause excitement in young children instead of drowsiness.Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness,low blood pressure, confusion,constipation, or trouble urinating. Drowsiness, dizziness, and confusion can increase the risk of falling.This medication should be used only when clearly needed duringpregnancy. Tell your doctor if you arepregnantbefore using this medication.This drug passes intobreast milkand may have undesirable effects on anursinginfant. Consult your doctor before breast-feeding.

QUESTION

Allergies can best be described as:See Answer

DRUG INTERACTIONS:Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), antispasmodics (e.g.,atropine, belladonna alkaloids), drugs for帕金森病(e.g., anticholinergics such asbenztropine, trihexyphenidyl), MAO inhibitors (isocarboxazid,linezolid,methylene blue, moclobemide, phenelzine, procarbazine,rasagiline,selegiline, tranylcypromine),tricyclic antidepressants(e.g.,amitriptyline).Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., dimenhydrinate), anti-seizuredrugs (e.g.,carbamazepine), medicine forsleeporanxiety(e.g.,阿普唑仑,diazepam,zolpidem), muscle relaxants, narcoticpainrelievers (e.g.,codeine), psychiatric medicines (e.g.,chlorpromazine,risperidone, amitriptyline,trazodone). Check the labels on all your medicines (e.g.,cough-and-coldproducts) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

OVERDOSE:If overdose is suspected, contact apoison controlcenter or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include large pupils, flushing,fever,hallucinations,weakness, shaking (tremor), muscle twitching,loss of consciousness, andseizures. In children, excitement may occur first, and may be followed by loss of coordination, drowsiness, loss of consciousness, and seizures.

NOTES:Do not take for several days beforeallergytesting. Test results can be affected.Do not share this medication with others.

MISSED DOSE:If you miss a dose, use it as soon you remember. If it is near the time of your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE:Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do notflushmedications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised November 2013. Copyright(c) 2013 First Databank, Inc.