What is endometrial biopsy procedure?

The uterus (womb) is lined by a special type of tissue known as theendometrium. Endometrial biopsy, or endometrial sampling, is a technique of removing a piece of tissue from the inner lining of the uterus. The sample of tissue is analyzed under a microscope in the laboratory by a pathologist, a doctor with special training in diagnosis of diseases based upon tissue examination.

Is endometrial biopsy painful?

Usually, endometrial biopsy procedures painful, and women who are having the procedure should be notified. There aredrugsto stop thepaincaused by the biopsy.Endometriosiscan have an impact psychologicaly on women with the condition due to severepain. Moreover, the severe pain caused byendometriosisis compounded negatively by the inability to conceive.

Why is endometrial biopsy done?

通常performe子宫内膜活检d to help determine the cause of abnormal uterine bleeding. It can also be done to help evaluate the cause ofinfertility, test for uterine infections, and even monitor the response to certain medications.

Endometrial biopsy has many advantages over the more complicated procedure known asdilation and curettage(D&C), which is a more extensive removal of the uterine lining that requires dilation (stretching) of the cervical opening with special instruments. Unlike D&C, endometrial biopsy may be performed in the doctor's office and typically does not require anesthesia or hospitalization.

Endometrial biopsy cannot be performed duringpregnancy, and sometimes may not be recommended when certain other conditions are present, includingcancer of the cervixor abnormal narrowing (stenosis) of the cervical opening.

How is endometrial biopsy done?

Endometrial biopsy is most often done in the physician's office, but it can be performed on women in the hospital. The patient lies on the examining table in a position similar to that used for obtaining Pap smears. The doctor uses a speculum to open the vaginal canal and visualize the cervix, the opening to the uterus. During endometrial biopsy the doctor inserts a thinplasticor metal tubular device through the cervix into the uterus to remove a tiny piece of the inner lining tissue.

Picture of the female reproductive system
Picture of the female reproductive system

Usually no anesthesia is required, but taking a nonsteroidal anti-inflammatory medication (NSAID) 30 to 60 minutes prior to the procedure can help reduce cramping and pain. In some cases, a small amount oflidocaineanesthetic is inserted into the uterinecavityto minimize discomfort.

What are the risks of endometrial biopsy?

There are very few risks with endometrial biopsy. The leading risk is pain or cramping, but this typically subsides rapidly following the procedure. Other less common risks are:

  1. Feeling faint or light-headed
  2. Infection
  3. Bleeding
  4. Rarely, perforation of the uterus

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What Is Endometriosis? Symptoms, Causes, TreatmentSee Slideshow

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References
REFERENCES:

Kuntz, C, MD, CCFP, FCFPO, et al. Endometrial Biopsy.Can Fam Physician. 2007 Jan; 53(1): 43–44.


Priore, G, MD, MPH. Endometrial sampling procedures. UptoDate. Updated: Oct 2018.
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