Giapreza (angiotensin II)

• Giapreza (angiotensin II) is a vasoconstrictor to increase官网地址bwinin adults with septic or other distributiveshock.
• Angiotensin II is a naturally occurring peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure.
• Giapreza is a sterile, aqueous solution of synthetic human angiotensin II for intravenous administration by infusion.

Common side effects of Giapreza include:

• blood clots,
• low platelet count(thrombocytopenia),
• fastheartrate,
• fungal infection,
• delirium,
• high levels of acid on the blood (acidosis),
• high blood sugar(hyperglycemia), and
• lack of blood flow to extremities

• The recommended starting dosage of Giapreza is 20 nanograms (ng)/kg/min via continuous intravenous infusion.
• Administration through a central venous line is recommended.
• 监测血压反应官网地址bwintitrate Giapreza every 5 minutes by increments of up to 15 ng/kg/min as needed to achieve or maintain target blood pressure.
• Do not exceed 80 ng/kg/min during the first 3 hours of treatment.
• Maintenance doses should not exceed 40 ng/kg/min.
• Doses as low as 1.25 ng/kg/min may be used.
• Once the underlying shock has sufficiently improved, down-titrate every 5 to 15 minutes by increments of up to 15 ng/kg/min based on blood pressure.

• Angiotensin Converting Enzyme (ACE) Inhibitors Concomitant use of angiotensin converting enzyme (ACE) inhibitors may increase the response to Giapreza.
• Angiotensin II Receptor Blockers(ARB)同时使用血管紧张素ⅱ受体blockers (ARBs) may decrease the response to Giapreza.

• The published data on angiotensin II use inpregnantwomen are not sufficient to determine a drug-associated risk of adverse developmental outcomes.
• It is not known whether Giapreza is present inhuman milk.
• No data are available on the effects of angiotensin II on thebreastfedchild or the effects on milk production.