What is guaifenesin with codeine, and how does it work (mechanism of action)?

Guaifenesinwithcodeineis an oral, liquidcough medicine. Guaifenesin is an expectorant, which works by thinning and increasing the volume ofmucus.Codeineis a narcoticcough suppressantthat works by suppressing thecoughreflex in the brain, eventually reducing the frequency ofcough.

What brand names are available for guaifenesin with codeine?

N/A

Is guaifenesin with codeine available as a generic drug?

Yes

Do I need a prescription for guaifenesin with codeine?

Yes

What are the side effects of guaifenesin with codeine?

Side effects of guaifenesin with codeine are:

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What is the dosage for guaifenesin with codeine?

  • Adults and children 12 years of age and older: Take 2 teaspoon (10 ml) by mouth every 4 hours as needed.
  • Children 6 years to 12 years of age: Take 1 teaspoon (5 ml) by mouth every 4 hours as needed.
  • Children 2 years to 6 years of age: Consult a doctor.
  • Children under 2 years of age: Do not use.
  • Do not use more than 6 doses in a 24-hour period.

Which drugs or supplements interact with guaifenesin with codeine?

Naltrexone (Riva) decreases the effect of codeine in the body, therefore codeine must not be used with naltrexone.

Any other medications that increase drowsiness should be used with caution with guaifenesin and codeine.

Is guaifenesin with codeine safe to take if I'm pregnant or breastfeeding?

There are no adequate studies with guaifenesin and codeine to determine its safety and effectiveness inpregnantwomen.

Guaifenesin with codeine is excreted inbreast milk; therefore, it must be used with caution innursingmothers.

What else should I know about guaifenesin with codeine?

What preparations of guaifenesin with codeine are available?

Guaifenesin with codeine phosphate is available as an oral liquid. One teaspoon (5 ml) of liquid contains 10 mg of codeine phosphate and 100 mg or 300 mg of guaifenesin.

How should I keep guaifenesin with codeine stored?

Guaifenesin and codeine liquid should be stored between 15 C to 30 C (59 F to 86 F).

Summary

Guaifenesin and codeine phosphate is a drug prescribed for the treatment of cough caused by conditions such as the flu, cold, bronchitis, or sinusitis. Side effects, drug interactions, and dosage information should be reviewed prior to taking this medication. There are no generic or brand names available for this drug. Previous brand names include Cheratussin AC, Codar GF, Dex-Tuss, Guaiatussin AC, Iophen C-NR, M-Clear WC, Mar-Cof CG, Virtussin A/C, Tussi-Organidin NR, and Mytussin AC.

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References
Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine

REFERENCES:

FDA Prescribing Information.
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