iron dextran (Dexferrum, INFeD)

Iron dextran is an injectable form of iron used to treat iron-deficiencyanemia, a condition in which the blood doesn't have enough healthy红细胞because of a deficiency of available iron. It is only used to treat patients who cannot be adequately treated with oraliron supplements. Iron is an important mineral and is a necessary component of red blood cells and their ability to carry oxygen. Ironsupplementsreplenish iron in the body and allow the transportation of oxygen.

What brand names are available for iron dextran injection?

INFeD, Pri-Dextra, and Dexferrum are the brand names available for this drug in the US.

Is this drug available as a generic drug?

No, iron dextran is not available in generic form.

Do I need a prescription for this drug?

Yes, you need a prescription from a doctor or other heatlh care professional for this medication.

Iron dextran is used to treat patients withiron deficiency anemiathat cannot be adequately treated with oral ironsupplements.

Serious anaphylactic-type reactions, including death, have occurred after administration of iron dextran injection. Resuscitation equipment and trained personnel should be available during administration.Patients should be given a test dose before their first dose and monitored closely by their doctor. However, fatal reactions have followed the test dose of iron dextran injection. Fatal reactions have also occurred even when the test dose was tolerated. The risk of experiencingallergictype side effects may be higher in patients who haveallergiesto otherdrugs.

Large doses may cause delayed (1-2 days) adverse reactions such as:

• Arthralgia
• Backache
• Chills
• Dizziness
• Moderate to highfever
• Headache
• Malaise
• Myalgia
• Nausea
• Vomiting

The reactions start 24-48 hours after administration and symptoms generally subside within 3-4 days.

Common side effects include:

• Loose stools(diarrhea)
• Headache
• Cramps
• Dizziness
• Upset stomach
• Change in taste
• Painand irritation or swelling where the injection was given

Other possible side effects include:

• Itching
• Rash
• Skin
• Reactions
• Nausea
• Vomiting
• Decreased white blood cell count
• Chest pain
• Low blood pressure
• High blood pressure
• Rapid heartbeat
• Slow heartbeat
• Flushing
• Abnormal heart rhythms
• Joint pain
• Muscle pain
• Seizures
• Breathingproblems
• Fever

Iron dextran is injected into a vein or the muscles of the buttocks.

The recommended dose for adults is 25-100 mg intravenously or deep into the muscle of the buttock everyday as needed. The maximum dose is 100 mg (2 mL) a day

No clinically important drug-drug interactionsbetween iron dextran and other medications have been reported by the manufacturer.

• There are no adequate and well-controlled studies inpregnantwomen. Iron dextran should be used duringpregnancyonly if the potential benefit justifies the potential risk to the fetus.
• Small amounts of iron dextran are excreted intohuman milk. Iron dextran should be used cautiously in pregnant women.

What preparations of iron dextran-injection are available?

Iron dextran solution is available in 2 ml single dose vials for injection, containing 50 mg of elemental iron per ml.

How should I keep iron dextran-injection stored?

Iron dextran should be stored at room temperature, between 68 F and 77 F (20 C to 25 C).

When was iron dextran approved by the FDA?

The FDA approved iron dextran in April, 1974.