Asacol vs. Humira
- BothAsacol(mesalamine) andHumira(adalimumab) are used to treat different kinds ofinflammatory bowel diseases．
- Asacol(mesalamineis an anti-inflammatory medication used to treatinflammatory bowel disease[IBD] includingulcerative colitis[UC]).
- Asacol is different fromHumira(adalimumab) which is an injectable protein (antibody) that is an immune modulator drug used to treat different autoimmune conditions includingarthritis,psoriasis,ulcerative colitis, and Crohn’s disease.
- Common side effects of Asacol include:
- mildnausea
- vomiting
- stomach cramps
- diarrhea
- gas
- fever
- sore throat
- flu-like symptoms
- constipation
- headache
- dizziness
- tired feeling
- skinrash
- Common side effects of Humira are different and include
- Asacol may interact withazathioprineormercaptopurine, pentamidine,tacrolimus, amphotericin B, antibiotics, antiviral medicines,cancermedicine, oraspirinor otherNSAIDs(nonsteroidal anti-inflammatorydrugs). Humira may interact with otherdrugs．
What are Asacol and Humira?
Asacol (mesalamine) is an anti-inflammatory drug used to treatulcerative colitis, proctitis, and proctosigmoiditis, and is also used to prevent thesymptoms of ulcerative colitisfrom recurring.
Humira (adalimumab) is an injectable protein (antibody) used to treatrheumatoid arthritis,juvenile idiopathic arthritis,psoriatic arthritis,ankylosing spondylitis, and plaquepsoriasis．Humira is also used to treat ulcerativecolitis其他药物后,克罗恩病tried without successful treatment of symptoms.
What are the side effects of Asacol and Humira?
Asacol
The most common side effects of mesalamine are:
- headache,
- flatulence,
- hair loss, and
- itching．
Infrequent side effects include:
- increasedheartrate,
- acne,
- pancreatitis,
- back pain,
- fatigue,
- tremor,
- earpain, and
- blood disorders．
Kidney dysfunction has been associated with mesalamine. Kidney function should be evaluated prior to and periodically during mesalamine therapy.
Mesalamine may cause an acute intolerance syndrome that resembles a flare ofinflammatory bowel disease(Crohn's disease orulcerative colitis) with cramping,abdominal pain, andbloody diarrhea．Fever,headache,itching, andrashalso may occur. Symptoms usually subside once mesalamine is discontinued.
Mesalamine enemas contain sulfites and should be avoided in persons who are sensitive to sulfites.
Since mesalamine is related toaspirinin structure, individuals who areallergicto aspirin should not take mesalamine.
Humira
The most common side effects are:
Adalimumab may cause swelling, redness,painanditchingat the site of injection. Adalimumab suppresses the immune system and is therefore associated with minor infections of the urinary tract, respiratory tract, and sinuses. Like other drugs that block TNF, use of adalimumab also has been associated with serious infections such astuberculosis,sepsis(bacteria in the blood) andfungal infections．Individuals with active infections should not be treated with adalimumab.
Adalimumab also may worsen the symptoms of diseases of the nervous system. In studies some patients who used adalimumab or other TNF blocking drugs developedcancer．Since patients withrheumatoid arthritishave a higher rate ofcancersthan the general population, the connection betweencancerand use of adalimumab is unclear.
Other side effects of adalimumab include:
- 过敏反应(包括anaphylaxis) and
- reduced levels in the blood of platelets andred cells(aplasticanemia).
Adalimumab may increase the risk of reactivatinghepatitis Bvirus in chronic carriers of the virus.
What is the dosage of Asacol vs. Humira?
Asacol
(see dosing instructions provided by manufacturer)
- Lialda: 2.4-4.8 g once daily with food
- Apriso: 1.5 g orally once daily
- Pentasa: 1 g four times daily
- Asacol HD: 1.6 g 3 times daily
- Delzicol: 800 mg 3 times daily (has replaced Asacol; also available in extended release tablets)
- Rowasa: One rectal application (4 g per 60 mL enema) once a day, preferably at bedtime, and retained for approximately 8 hours.
- Canasa: One suppository (1,000 mg) daily at bedtime. The suppository should be retained in the rectum for one to three hours or more if possible to achieve maximum benefit.
Humira
Adalimumab is injected under the skin. The recommended dose forrheumatoid arthritis,ankylosing spondylitis, andpsoriatic arthritisis 40 mg every other week, but some patients may need weekly administration.
Crohn's disease is treated with 160 mg initially, followed by 80 mg two weeks later, then 40 mg every 2 weeks.
Juvenile idiopathic arthritisis treated with 20 or 40 mg every other week and plaquepsoriasisis treated with 80 mg followed by 40 mg every other week.
What drugs interact with Asacol and Humira?
Asacol
Oral mesalamine formulations are associated with severaldrug interactions．Combining mesalamine with drugs that affect kidney function, for example,nonsteroidal antiinflammatory drugs(NSAIDs) oribuprofenmay increase the likelihood of reduced function of the kidneys. Concurrent use of mesalamine and 6-mercaptopurineorazathioprine(Imuran) may increase the likelihood of disorders of the blood cells, particularly reduced numbers of cells. Mesalamine may increase the blood thinning effect ofwarfarin(Coumadin).
Humira
Adalimumab is injected under the skin. The recommended dose forrheumatoid arthritis,ankylosing spondylitis, andpsoriatic arthritisis 40 mg every other week, but some patients may need weekly administration.
Crohn's disease is treated with 160 mg initially, followed by 80 mg two weeks later, then 40 mg every 2 weeks.
Juvenile idiopathic arthritisis treated with 20 or 40 mg every other week and plaquepsoriasisis treated with 80 mg followed by 40 mg every other week.
Are Asacol and Humira safe to take while pregnant or breastfeeding?
Asacol
There are no adequate human studies of mesalamine duringpregnancy．Mesalamine is known to cross the placenta into the fetus, but animal studies revealed no evidence of harm to the fetus. Mesalamine should only be used duringpregnancyif it is felt that the benefit of its use justifies the unknown risks.
Mesalamine is excreted inbreast milk．Mesalamine should only be used bynursingmothers if it is felt that the benefit of its use justifies the potential but unknown risk to the infant.
Humira
Adalimumab has not been adequately studied inpregnantwomen.
Use of adalimumab bynursingmothers has not been adequately evaluated.
Summary
BothAsacol(mesalamine) andHumira(adalimumab) are used to treat different kinds ofinflammatory bowel diseases．抗也是一个通用anti-inflammatory used to treat other autoimmune conditions including:
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炎症Bowel Disease (IBD)
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肠易激综合症(肠易激综合症)和炎症性肠病(inflammatory bowel disease) are both problems with the digestive tract (gastrointestinal or GI tract), but they are not the same disease. IBS is a functional disorder (a problem with the way the GI tract functions), and IBD is a disease that causes chronic prolonged inflammation of the GI tract, that can lead to ulcers and other problems that may require surgery. The most common forms of IBD are Crohn's disease and ulcerative colitis, or UC. Researchers do not know the exact cause of either disease, but they believe that IBS may be caused and triggered by a variety of factors (foods, stress, and the nervous system of the GI tract), while IBD may be genetic or due a problem with the immune system.Common symptoms of both diseases are an urgent need to have a bowel movement, diarrhea, nausea, vomiting, and abdominal pain and cramping. There are differences between the signs and symptoms of irritable bowel syndrome and inflammatory bowel disease, for example, symptoms unique to IBD are: Fever Joint pain or soreness Skin changes Rectal bleeding Anemia Eye redness or pain Unintentional weight loss Feeling tired Symptoms unique to irritable bowel syndrome include: Sexual problems Fibromyalgia Abdominal bloating Whitish mucous in the stool Changes in bowel movements and in the way stools look An urgent need to urinate Urinating frequently Treatment for IBS is with diet recommendations from a doctor or nutritionist, medication, and lifestyle changes like stress management and avoiding foods that trigger the condition. Treatments for IBD depend upon the type of disease, its symptoms, and health of the patient. Surgery may be necessary for some individuals.REFERENCES: Brown, AC, et al. "Existing Dietary Guidelines for Crohn's Disease and Ulcerative Colitis." Medscape. Lehrer, J. "Irritable Bowel Syndrome." Medscape. Updated: Apr 04, 2017. Rowe, W. "Inflammatory Bowel Disease." Medscape. Updated: Jun 17, 2016. Romanowski, A, MS, RD. "Matching the Right Diet to the Right Patient." Medscape. Jan 27, 2017.
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adalimumab (Humira)
Adalimumab (Humira) is a drug prescribed for reducing the symptoms and signs of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, juvenile idiopathic arthritis, and Crohn's disease. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.Crohn's Disease vs. Ulcerative Colitis (UC)
Crohn's disease and ulcerative colitis are diseases that cause inflammation of part of or the entire digestive tract (GI). Crohn's affects the entire GI tract (from the mouth to the anus), while ulcerative colitis or ulcerative colitis only affects the large and small intestine and ilium. Researchers do not know the exact cause of either disease. About 20% of people with Crohn's disease also have a family member with the disease. Researchers believe that certain factors may play a role in causing UC. Both Crohn's disease and ulcerative colitis are a type of inflammatory bowel disease, or IBD.Crohn's disease and ulcerative colitis both have similar symptoms and signs, for example, nausea, loss of appetite, fatigue, weight loss, episodic and/or persistent diarrhea, fever, abdominal pain and cramping, rectal bleeding, bloody stools, joint pain and soreness, eye redness, or pain. Symptoms unique to Crohn’s disease include anemia and skin changes. Symptoms of unique to ulcerative colitis include, certain rashes, an urgency to defecate (have a bowel movement). Doctors diagnose both diseases with similar tests and procedures. While there is no cure for either disease, doctors and other health care professionals can help you treat disease flares, and manage your Crohn's or ulcerative colitis with medication, diet, nutritional supplements, and/or surgery.
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肠易激综合症(肠易激综合症)和炎症性肠病(inflammatory bowel disease) are both problems with the digestive tract (gastrointestinal or GI tract), but they are not the same disease. IBS is a functional disorder (a problem with the way the GI tract functions), and IBD is a disease that causes chronic prolonged inflammation of the GI tract, that can lead to ulcers and other problems that may require surgery. The most common forms of IBD are Crohn's disease and ulcerative colitis, or UC.
Researchers do not know the exact cause of either disease, but they believe that IBS may be caused and triggered by a variety of factors (foods, stress, and the nervous system of the GI tract), while IBD may be genetic or due a problem with the immune system.
Common symptoms of both diseases are an urgent need to have a bowel movement, diarrhea, nausea, vomiting, and abdominal pain and cramping.
There are differences between the signs and symptoms of irritable bowel syndrome and inflammatory bowel disease, for example, symptoms unique to IBD are:- Fever
- Joint pain or soreness
- Skin changes
- Rectal bleeding
- Anemia
- Eye redness or pain
- Unintentional weight loss
- Feeling tired
Symptoms unique to irritable bowel syndrome include:- Sexual problems
- Fibromyalgia
- Abdominal bloating
- Whitish mucous in the stool
- Changes in bowel movements and in the way stools look
- An urgent need to urinate
- Urinating frequently
Treatment for IBS is with diet recommendations from a doctor or nutritionist, medication, and lifestyle changes like stress management and avoiding foods that trigger the condition. Treatments for IBD depend upon the type of disease, its symptoms, and health of the patient. Surgery may be necessary for some individuals.
REFERENCES:
Brown, AC, et al. "Existing Dietary Guidelines for Crohn's Disease and Ulcerative Colitis." Medscape.
Lehrer, J. "Irritable Bowel Syndrome." Medscape. Updated: Apr 04, 2017.
Rowe, W. "Inflammatory Bowel Disease." Medscape. Updated: Jun 17, 2016.
Romanowski, A, MS, RD. "Matching the Right Diet to the Right Patient." Medscape. Jan 27, 2017.炎症Bowel Disease (IBD) Diet
炎症bowel disease (IBD) is a name for a group of diseases in which there is inflammation of the digestive tract (gastrointestinal tract). Crohn's disease and ulcerative colitis (UC) are the most common types of inflammatory bowel disease. While there is no specific recommended diet for a person with IBD, doctors and specialists recommend a low-residue (low fiber) diet for people with inflammatory bowel disease. Nutritionists, registered dieticians, and other health-care professionals can recommend specific foods, create meal plans, and recommend vitamins and other nutritional supplements.
Foods to avoid with IBD- Examples of foods to avoid that may trigger symptoms include if you have IBD include products alcohol, diary products, fatty, fried, and spicy foods, beans, and creamy sauces.
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Mesalamine (Pentasa Rowasa、SfRowasa Lialda,可以asa, Apriso, Delzicol) is a medication prescribed for ulcerative colitis and mild to moderate Crohn's disease. Side effects, drug interactions, warnings and precautions, and safety during pregnancy information should be reviewed prior to taking this medication.mesalamine (Lialda)
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Psoriasis is a long-term skin condition that may cause large plaques of red, raised skin, flakes of dry skin, and skin scales. There are several types of psoriasis, including psoriasis vulgaris, guttate psoriasis, inverse psoriasis, and pustular psoriasis. Symptoms vary depending on the type of psoriasis the patient has. Treatment of psoriasis may include creams, lotions, oral medications, injections and infusions of biologics, and light therapy. There is no cure for psoriasis.Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease resulting in chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Early RA signs and symptoms include anemia, both sides of the body affected (symmetric), depression, fatigue, fever, joint deformity, joint pain, joint redness, joint stiffness, joint swelling, joint tenderness, joint warmth, limping, loss of joint function, loss of joint range of motion, and polyarthritis.16 Early Rheumatoid Arthritis (RA) Signs & Symptoms
Early rheumatoid arthritis (RA) symptoms and signs vary differently from person to person. The most common body parts that are initially affected by RA include the small joints of the hands, wrists, and feet, and the knees and hip joints. Joint inflammation causes stiffness. Warmth, redness, and pain may vary in degree.Rheumatoid Arthritis vs. Arthritis
Arthritis is a general term used to describe joint disease. Rheumatoid arthritis (RA) is a type of arthritis in which the body’s immune system mistakenly attacks the joints, causing chronic inflammation.