Does Thalitone (chlorthalidone) cause side effects?
Thalitone(chlorthalidone) is a thiazide diuretic used in the treatment ofhigh blood pressure,congestive heart failure, and水肿(fluid retention). The brand name Thalitone is discontinued in the U.S.
Common side effects of Thalitone include
Serious side effects of Thalitone include
- low blood levels of potassium, sodium, and magnesium due to increased excretion via urine;
- high blood calcium levels, especially in persons who are taking钙补充剂;
- increased levels of uric acid in the blood (butgoutrarely occurs), and
- high blood sugars in patients withdiabetes.
Drug interactionsof Thalitone include loop diuretics such asfurosemide,bumetanide, andtorsemide, because Thalitone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine.
- Low potassiumand magnesium levels can lead toabnormal heart rhythms, especially in patients takingdigoxin. Thalitone reduces the kidney's ability to eliminatelithiumin the urine. As a result, patients taking Thalitone at the same time asdrugscontaining lithium may develop high levels of lithium and lithium toxicity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the effectiveness of Thalitone though the reason for this is not clear.
- Bloodsugarlevels can be elevated bythiazide diuretics. Patients withdiabetesmay need to adjust the doses of medications they are taking for treatingdiabetes.
噻嗪类利尿剂包括Thalitone placenta and can causejaundicein the fetus ornewborn. Thalitone should not be used duringpregnancyunless absolutely necessary.
Large doses of thiazide diuretics may suppress milk production, but the American Academy ofPediatricsconsidersthiazidesto be compatible withbreastfeeding.
What are the important side effects of Thalitone (chlorthalidone)?
Chlorthalidone generally is well tolerated.
Side effects include:
- dizziness,
- lightheadedness,
- headache,
- fatigue,
- nausea,
- vomiting,
- abdominal pain, and
- constipation.
More serious side effects include:
- Low blood levels of potassium, sodium, and magnesium due to increased excretion via urine.
- High blood calcium levels also can occur, especially in persons who are taking calciumsupplements.
- Thiazide diuretics such as chlorthalidone increase the levels of uric acid in the blood, butgout(which is caused by high levels of uric acid) rarely occurs.
- Chlorthalidone can cause high blood sugars in patients with diabetes.
Thalitone (chlorthalidone) side effects list for healthcare professionals
The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.
- Gastrointestinal System Reactions:anorexia,gastricirritation,nausea, vomiting, cramping,diarrhea,constipation,jaundice(intrahepaticcholestaticjaundice),pancreatitis.
- Central Nervous System Reactions:dizziness,vertigo, paresthesias,headache,xanthopsia.
- Hematologic Reactions:leukopenia,agranulocytosis,thrombocytopenia,aplastic anemia.
- Dermatologic-Hypersensitivity Reactions:purpura,光敏性,rash,urticaria, necrotizingangiitis(vasculitis) (cutaneousvasculitis), Lyell'ssyndrome(toxicepidermalnecrolysis).
- Cardiovascular Reaction:Orthostatic hypotensionmay occur and may be aggravated byalcohol,barbituratesor narcotics.
- Other Adverse Reactions:hyperglycemia, glycosuria,hyperuricemia,musclespasm,weakness,restlessness,impotence.
Whenever adverse reactions are moderate or severe, chlorthalidone dosage should be reduced ortherapywithdrawn.
What drugs interact with Thalitone (chlorthalidone)?
- Chlorthalidone may add to or potentiate the action of otherantihypertensivedrugs.
- Insulinrequirements in diabetic patients may be increased, decreased or unchanged. Higher dosage of oralhypoglycemicagents may be required.
- Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.
- 氯噻酮及相关药物可能会降低法国当代艺术rial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of thepressoragent fortherapeuticuse.
- Lithiumrenalclearance is reduced by chlorthalidone,increasing the risk of lithiumtoxicity.
Drug/Laboratory Test Interactions
Summary
Thalitone(氯噻酮)是一个噻嗪类利尿剂used in the treatment of high blood pressure, congestive heart failure, and edema (fluid retention). Common side effects of Thalitone include dizziness, lightheadedness, headache, fatigue, nausea, vomiting, abdominal pain, and constipation. Thiazide diuretics including Thalitone cross the placenta and can cause jaundice in the fetus or newborn. Thalitone should not be used during pregnancy unless absolutely necessary. Large doses of thiazide diuretics may suppress milk production, but the American Academy of Pediatrics considers thiazides to be compatible with breastfeeding.
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Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.