Blood Protein Might Predict Future Diabetes, Cancer Risk

Elevated levels of a specific protein appear to be linked to an increased risk of developingdiabetesand dying fromcancer, a new study finds.

High levels of prostasin -- mainly found in epithelial cells, which line the surfaces and organs of the body -- are associated with bothdiabetesandcancer, researchers report Aug. 4 in the journalDiabetologia.

For this study, researchers analyzed blood samples taken from nearly 4,700 middle-aged Swedish adults as part of a large study that's beenrunningsince 1993.

Prostasin helps regulate sodium balance, blood volume and官网地址bwin, researchers said in background notes. The protein is also associated with metabolism of blood glucose.

Over an average 22-year follow-up, participants with the highest levels of prostasin were 76% more likely to developdiabetesthan those with the lowest levels, researchers found. Further, people with the highest prostasin blood levels are 43% more likely to die fromcancerthan those with the lowest levels.

For each doubling of prostasin concentrations in the blood, risk ofcancerdeath increased by 139% among people withhigh blood sugarlevels, the results showed.

人们不升高血糖,each doubling of prostasin concentration increasedcancerdeath risk by 24%.

"Prostasin is a new potential risk marker for the development ofdiabetesand forcancermortality, especially in individuals with high blood glucose levels," said lead researcher Dr. Xue Bao, of the Affiliated Hospital of Nanjing University Medical School in China.

"It is easily accessible, which enhances its potential to serve as a warning marker in the future," Bao said in a journal news release.

Prostasin levels better predicteddiabetesin younger participants, as well as those with lower blood glucose levels and better kidney function, researchers said. Elevated prostasin levels may compensate for the body's response to overly high bloodsugar, but appears to be insufficient to stop or reverse worsening glucose control.

More information

The AmericanDiabetesAssociation has more about diabetes and cancer.

SOURCE:Diabetologia,news release, Aug. 4, 2022

By Dennis Thompson HealthDay Reporter

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QUESTION

______________ is another term for type 2 diabetes.See Answer