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- What is tolmetin, and how does it work (mechanism of action)?
- What are the uses for tolmetin?
- What are the side effects of tolmetin?
- What is the dosage for tolmetin?
- Which drugs or supplements interact with tolmetin?
- Is tolmetin safe to take if I'm pregnant or breastfeeding?
- What else should I know about tolmetin?
What is tolmetin, and how does it work (mechanism of action)?
Tolmetin is anonsteroidal anti-inflammatory drug(NSAID) that is effective in treatingfever,pain, and inflammation in the body. It is similar toibuprofen(MotrinorAdvil),naproxen(Naprosyn), and others. As a group,NSAIDsare non-narcotic relievers of mild to moderatepainof many causes, including injury,menstrual cramps,arthritis, and other musculoskeletal conditions. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain,fever, and inflammation. Tolmetin blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved Tolectin in March 1976.
Is tolmetin available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for tolmetin?
Yes
What are the uses for tolmetin?
What are the side effects of tolmetin?
Most patients benefit from tolmetin and other NSAIDs with few side effects. However, serious side effects can occur, and generally tend to be dose related. Therefore, it is advisable to use the lowest effective dose to minimize side effects. The most common side effects of tolmetin involve the gastrointestinal system, and these include:
- ulcerations,
- abdominal pain,
- cramping,
- nausea,
- gastritis,
- serious gastrointestinal bleeding,
- livertoxicity,
- stomach ulceration
- blacktarry stools, and
- weakness.
Tolmetin should be avoided by patients with a history ofasthma,hives, or otherallergicreactions toaspirinor other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients withpeptic ulcerdisease or poor kidney function, since this medication can aggravate both conditions.
Other important side effects include:
- heart attacks
- strokes
- accumulation of fluid, and
- increased chance ofheart failure.
Tolmetin may cause or worsenhigh blood pressureandkidney failure.
What is the dosage for tolmetin?
The recommended dose is 200-600 mg three times daily. The maximum daily dose is 1800 mg. Tolmetin should be taken with food and 8-12 ounces of water to avoid stomach upset.
SLIDESHOW
See SlideshowWhich drugs or supplements interact with tolmetin?
Tolmetin is generally used with caution in patients taking blood thinning medications (anticoagulants), such aswarfarin(Coumadin), because of an increased risk of bleeding. Patients takinglithium(Eskalith,Lithobid) ormethotrexate(Rheumatrex,Trexall) can develop toxic blood levels of either drug because tolmetin may inhibit their elimination from the body by the kidney. Side effects fromcyclosporinealso may be increased by tolmetin. Tolmetin may reduce the effectiveness of antihypertensives because it causes or worsenshigh blood pressure. NSAIDs may diminish the antihypertensive effect ofACE inhibitors.
Combining NSAIDs with angiotensin receptor blockers (for example,valsartan[Diovan],losartan[Cozaar],irbesartan[Avapro]) or angiotensin converting enzyme inhibitors (for example,enalapril[Vasotec],captopril[Capoten]) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, includingkidney failure. These effects usually are reversible.
Persons who have more than three alcoholicbeveragesper day are at increased risk of developing stomach ulcers when taking tolmetin or other NSAIDs.
Is tolmetin safe to take if I'm pregnant or breastfeeding?
Tolmetin is generally avoided duringpregnancy.
Tolmetin is excreted inbreast milk. To avoid adverse effects in the infant,nursingmothers should decide whether to stop nursing or stop tolmetin.
What else should I know about tolmetin?
What preparations of tolmetin are available?
Tablets or capsules: 200, 400, and 600 mg
How should I keep tolmetin stored?
Tolmetin should be stored at room temperature in a sealed container and protected from moisture.
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Summary
Tolmetin (Tolectin [Discontinued Brand]) is a nonsteroidal anti-inflammatory drug (NSAID) prescribed for the treatment of inflammation and pain that results from rheumatoid arthritis, juvenile arthritis, or osteoarthritis. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.
Related Disease Conditions
-
风湿性Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Early RA signs and symptoms include anemia, both sides of the body affected (symmetric), depression, fatigue, fever, joint deformity, joint pain, joint redness, joint stiffness, joint swelling, joint tenderness, joint warmth, limping, loss of joint function, loss of joint range of motion, and polyarthritis.
-
Osteoarthritis (OA)
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
-
Arthritis (Joint Inflammation)
关节炎是一个或多个关节的炎症。When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
-
疼痛管理
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
-
Ankylosing Spondylitis
Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. The tendency to develop ankylosing spondylitis is genetically inherited. Treatment incorporates medications, physical therapy, and exercise.
-
Psoriatic Arthritis
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms and signs include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves anti-inflammatory medications and exercise.
-
Ankle Pain (Tendonitis)
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammation.
-
Nonsteroidal Anti-inflammatory Drugs and Ulcers
Nonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of NSAIDs include aspirin, ibuprofen, naproxen, and more. One common side effect of NSAIDs is peptic ulcer (ulcers of the esophagus, stomach, or duodenum). Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking NSAIDs.
-
Reactive Arthritis
Reactive arthritis is a chronic, systemic rheumatic disease characterized by three conditions, including conjunctivitis, joint inflammation, and genital, urinary, or gastrointestinal system inflammation. Inflammation leads to pain, swelling, warmth, redness, and stiffness of the affected joints. Non-joint areas may experience irritation and pain. Treatment for reactive arthritis depends on which area of the body is affected. Joint inflammation is treated with anti-inflammatory medications.
-
SAPHOSyndrome
SAPHOsyndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO syndrome is an eponym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. SAPHO syndrome is related to arthritic conditions such as ankylosing spondylitis and reactive arthritis. Treatment is directed toward the individual symptoms that are present, and includes medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), and cortisone medications.
-
Juvenile Rheumatoid Arthritis (JRA)
Juvenile rheumatoid arthritis (JRA) annually affects one child in every thousand. There are six types of JRA. Treatment of juvenile arthritis depends upon the type the child has and should focus on treating the symptoms that manifest.
Treatment & Diagnosis
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Medications & Supplements
- Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
- ibuprofen
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- celecoxib (Celebrex)
- naproxen
- indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)
- etodolac, Lodine (Discontinued)
- flurbiprofen (Ansaid)
- sulindac (Clinoril)
- diflunisal (Dolobid)
- valdecoxib, Bextra
- Side Effects of Tolectin (tolmetin)
- fenoprofen (Nalfon)
Prevention & Wellness
QUESTION
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit theFDA MedWatchwebsite or call 1-800-FDA-1088.